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Cell Based Assays
Drug Target Screening

Process Chain

Project Planning
Molecular Biology, Expression Systems
Cell Line Development
Media Development
Fermentation Development
Purification Development
Analytical Development

EUGENEX system for eucaryotic gene expression

High Level Expression under Serum- and Protein-Free Culture Conditions

Proprietary or patent-free expression systems:
The expression cassettes in pEGX plasmids are optimized with respect to promoter and enhancer elements, poly adenylation and splicing signals. In combination with our serum- and protein-free growing CHOSI cell lines we reached product concentrations up to 120 mg/l at the end of a batch culture. For two phase production systems (e.g. for expression of cytotoxic proteins) we use inducible expression vectors.

The pEGX high-level-expression vectors are available with different selection systems:
  • amplificable markers for increased productivity
  • novel affordable marker system for continuous selection in long term and large scale processes.


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